POTENSI IMUNOMODULATOR BIJI KOPI ROBUSTA TERHADAP KARIES GIGI

Abstract

Currently immunomodulator being a topic of conversation in the world of health is used as a prevention or treatment of various diseases. Kpi seeds suspected potentially be imunomdulator. The immune response of dental caries as fagositosisIL-1β, IL-1α and TNF-α. Aim. analyzing modulation of the immune response robusta coffee beans against dental caries. Method. Method. Using experimental animals, which are divided into 5 groups (each with 4 tails). KO: untreated group, KP1; the group made a hole in the tooth + by Kaping CaOH2. KP2: group made a hole in the tooth + by Kaping coffee bean paste fillings 25% + while. KP3: group made a hole in the tooth + by Kaping coffee bean paste fillings 50% + while KP4: group made a hole in the tooth + by Kaping coffee bean paste fillings 75% + while. Week 1, 2, week 3 mice were sacrificed to make the preparation of the teeth and surrounding tissues were for analysis of inflammatory cells, the cell number odontoblasts, the number of se osteoclasts, the sheer number of osteoblasts, the number of fibroblasts with painting HE, the expression of TNF-α, IL-1, by immunohistochemistry. Results. Day 7, 14, dominated the group of inflammatory cells pasta coffee and Ca (OH) 2 numbers looked down but did not differ. SCARA significant number of osteoblasts. Day 21 was dominated by fibroblasts, where coffee and Ca (OH) 2 is no different. Result. Robusta coffee bean and Ca (OH) 2 is equally as having the ability to reduce inflammation, expression of TNF-alpha and IL-1 beta, osteoclasts and improving odontoblasts and osteoblasts. Conclusion. Robusta coffee beans can be used as an alternative material pulp capping