Please use this identifier to cite or link to this item:
https://repository.unej.ac.id/xmlui/handle/123456789/77168
Title: | N-PHENYLBENZAMIDE SYNTHESIS BY NUCLEOPHILIC SUBSTITUTION WITH 1,3- DIPHENYLTHIOUREA |
Authors: | INDAH PURNAMA SARY |
Keywords: | N-phenylbenzamide 1,3-diphenylthiourea Imino alcohol-amide tautomerism Rearrangement intermediate |
Issue Date: | 28-Sep-2016 |
Abstract: | Objective: N-phenylbenzamides are important and biologically active compounds. N-phenylbenzamides have been synthesized by some routes. An attempt has been made to find out the new route to synthesize N-phenylbenzamides. Methods: The reaction was carried out by reacting substituted benzoyl chlorides with 1,3-diphenylthiourea in the presence of triethylamine in THF at 70 °C. After 4hr the product was purified and identified. Results: An excellent and pure yield of N-phenylbenzamides was obtained by reacting substituted benzoyl chlorides with 1,3-diphenylthiourea. The proposed mechanism follows imino alcohol-amide tautomerism and suggests the involvement of rearrangement intermediate. Conclusion: 1,3-diphenylthiourea is inexpensive commodity chemical and it is found to be the useful reagent for the direct conversion to Nphenylbenzamide. The proposed mechanism follows imino alcohol-amide tautomerism and suggests the involvement of rearrangement intermediate. The synthesis gave pure, high yield, and the one and only isolated product. |
Description: | International Journal of Pharmacy and Pharmaceutical Sciences Vol 7, Issue 3, 2015 |
URI: | http://repository.unej.ac.id/handle/123456789/77168 |
ISSN: | 0975 – 1491 |
Appears in Collections: | LSP-Article In Journal |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
IJPPS_Indah.pdf | 1.68 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.