Please use this identifier to cite or link to this item:
https://repository.unej.ac.id/xmlui/handle/123456789/77168
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | INDAH PURNAMA SARY | - |
dc.date.accessioned | 2016-09-28T03:03:11Z | - |
dc.date.available | 2016-09-28T03:03:11Z | - |
dc.date.issued | 2016-09-28 | - |
dc.identifier.issn | 0975 – 1491 | - |
dc.identifier.uri | http://repository.unej.ac.id/handle/123456789/77168 | - |
dc.description | International Journal of Pharmacy and Pharmaceutical Sciences Vol 7, Issue 3, 2015 | en_US |
dc.description.abstract | Objective: N-phenylbenzamides are important and biologically active compounds. N-phenylbenzamides have been synthesized by some routes. An attempt has been made to find out the new route to synthesize N-phenylbenzamides. Methods: The reaction was carried out by reacting substituted benzoyl chlorides with 1,3-diphenylthiourea in the presence of triethylamine in THF at 70 °C. After 4hr the product was purified and identified. Results: An excellent and pure yield of N-phenylbenzamides was obtained by reacting substituted benzoyl chlorides with 1,3-diphenylthiourea. The proposed mechanism follows imino alcohol-amide tautomerism and suggests the involvement of rearrangement intermediate. Conclusion: 1,3-diphenylthiourea is inexpensive commodity chemical and it is found to be the useful reagent for the direct conversion to Nphenylbenzamide. The proposed mechanism follows imino alcohol-amide tautomerism and suggests the involvement of rearrangement intermediate. The synthesis gave pure, high yield, and the one and only isolated product. | en_US |
dc.language.iso | id | en_US |
dc.subject | N-phenylbenzamide | en_US |
dc.subject | 1,3-diphenylthiourea | en_US |
dc.subject | Imino alcohol-amide tautomerism | en_US |
dc.subject | Rearrangement intermediate | en_US |
dc.title | N-PHENYLBENZAMIDE SYNTHESIS BY NUCLEOPHILIC SUBSTITUTION WITH 1,3- DIPHENYLTHIOUREA | en_US |
dc.type | Article | en_US |
Appears in Collections: | LSP-Article In Journal |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
IJPPS_Indah.pdf | 1.68 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.