Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/73885
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dc.contributor.authorIrawan, Eka Deddy-
dc.contributor.authorMunawaroh, Siti-
dc.contributor.authorSari, Lusia Oktora Ruma Kumala-
dc.date.accessioned2016-05-11T06:58:53Z-
dc.date.available2016-05-11T06:58:53Z-
dc.date.issued2016-05-11-
dc.identifier.issn1693-6485-
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/73885-
dc.description.abstractThe purpose of this study is to provide controlled release dosage by avoiding first pass metabolism and enzymatic degradation. Propranolol hydrochloride mucoadhesive buccal tablets was prepared by direct compression method using carbopol and CMC Na as buccal mucoadhesive polymer. Buccal mucoadhesive strength measured using buccal mucosa of gout. Testing the release of propranolol hydrochloride was determined by dissolution test using phosphate buffer solution pH 6,8 for 8 hours. Dissolution efficiency (DE) was calculated to describe the overall release profiles and used in determining the optimum response. The optimum region is determined using factorial design with the design criteria of response force for 20-40 grams of mucoadhesive buccal and DE 480 between 45-55%. The amount of carbopol that can provide the optimum response is between the range of 53,27-55 mg while the amount of CMC Na can provide the optimum response range is between 70-100 mg.en_US
dc.language.isoiden_US
dc.subjectbuccal mucoadhesiveen_US
dc.subjectpropranolol hydrochlorideen_US
dc.subjectCarbopolen_US
dc.subjectCMC Naen_US
dc.titleOPTIMASI KOMPOSISI KARBOPOL DAN NATRIUM KARBOKSIMETILSELULOSA SEBAGAI SISTEM BUCCAL MUCOADHESIVE TABLET PROPRANOLOL HIDROKLORIDAen_US
dc.typeArticleen_US
Appears in Collections:LSP-Jurnal Ilmiah Dosen

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