KAJIAN STRUKTUR SENYAWA TURUNAN ASAM NAFTIL PROPIONAT SEBAGAI KANDIDAT OBAT ANTIRADANG BUKAN STEROID

Abstract

Anti-inflammatory activities of naphthyl propionic acid and its derivatives had been studied by molecular mechanics using ChemOffice® 2004 software. Results showed that anti-inflammatory activity of these compounds seem to be determined by a presence of sinister stereochemical configuration of the asymmetric centre of carbon 2 of substituted propionic acid, a presence of an acidic functional group at the carbon 2’ of naphthyl ring, a presence of a heteroatomic substituent having negative inductive effect at the carbon 6’ of naphthyl ring, and interatomic distance between heteroatom-bound H atom and naphthyl ring of 3.128 ± 0.575 Å with the optimum distance of 3.264 Å for naproxen.