Influence of chronic pesticide exposure on malondialdehyde and 8-OHdG levels among Wuluhan farmers, Jember, Indonesia: a cross-sectional study

Abstract

Chronic pesticide exposure causes oxidative stress and DNA damage in humans, with long-term health implications. This study aims to assess chronic pesticide exposure with oxidative stress and DNA damage biomarkers among farmers in Wuluhan District, Jember, Indonesia. Methods Seventy-four farmers from two villages in Wuluhan, Jember, were interviewed regarding pesticide exposure using a questionnaire, and serum MDA and urine 8-OHdG were examined. Thirty-six subjects from the first village had low-moderate intensity, and 38 subjects from the second village had high spraying intensity before the test. Data were analyzed by Spearman correlation tests between the chronic pesticide exposure index, MDA serum, and urinary 8-OHdG in each group.