Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/118384
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dc.contributor.authorERISADANA, Rifaldy Nabiel-
dc.contributor.authorSUPRANOTO, Yehuda Tri Nugroho-
dc.contributor.authorFATMAWATI, Heni-
dc.contributor.authorKUSUMA, Irawan Fajar-
dc.contributor.authorWIBISONO, Adrian-
dc.contributor.authorLESTARI, Putu Ayu Laksmi-
dc.date.accessioned2023-10-23T01:55:26Z-
dc.date.available2023-10-23T01:55:26Z-
dc.date.issued2023-04-26-
dc.identifier.urihttps://repository.unej.ac.id/xmlui/handle/123456789/118384-
dc.description.abstractAblation modalities for the treatment of hepatocellular carcinoma (HCC) including microwave ablation (MWA) and radiofrequency ablation (RFA) are clinically important due to their numerous advantages. Several trials showed inconsistent results regarding safety and efficacy, making the comparison between MWA and RFA challenging. Therefore, this study aimed to enhance the evidence on treatment modalities regarding the clinical efficacy and safety of MWA compared to RFA in HCC patients. Methods: A systematic review and meta-analysis was conducted following the PRISMA guidelines. Subsequently, a literature search was carried out by PubMed, ScienceDirect, and Google Scholar for randomized controlled trials (RCTs) in HCC patients who passed through MWA compared to RFA. Quantitative analysis of pooled risk ratio with a 95% confidence interval was performed using Review Manager 5.4 software in a random-effects model or fixed-effects model forest plot. Results: Based on 9 RCTs included in the analysis, there were insignificant different results in terms of complete ablation rates (CA) [RR=1.01, 95%CI (0.99 to 1.03), p=0.47] and adverse events (AE) [RR=1.15, 95%CI (0.88 to 1.50), p=0.31]. However, lower incidence of local tumor progression (LTP) [RR=0.73, 95%CI (0.54 to 0.99), p=0.04], intrahepatic de novo lesions (IDL) [RR=0.90, 95%CI (0.81 to 1.00), p=0.05], and extrahepatic metastases (EHM) [RR=0.65, 95%CI (0.44 to 0.95), p=0.03] exhibited significant differences in MWA group. Conclusions: This meta-analysis provided evidence that MWA and RFA had equivalent CA rates and AE in HCC patients. However, MWA was considered superior to RFA due to a lower incidence of LTP, IDL, and EHM.en_US
dc.language.isoenen_US
dc.publisherIndonesian Journal of canceren_US
dc.subjecthepatocellular carcinomaen_US
dc.subjectmeta-analysisen_US
dc.subjectmicrowave ablationen_US
dc.subjectradiofrequency ablationen_US
dc.titleClinical Efficacy and Safety of Microwave Ablation Compared to Radiofrequency Ablation in Hepatocellular Carcinoma Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trialsen_US
dc.typeArticleen_US
Appears in Collections:LSP-Jurnal Ilmiah Dosen

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