Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/117696
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dc.contributor.authorELFIAH, Ulfa-
dc.contributor.authorPERDANAKUSUMA, David Sontani-
dc.contributor.authorSAPUTRO, Iswinarno Doso-
dc.contributor.authorMISNAWI, Misnawi-
dc.date.accessioned2023-08-23T06:09:54Z-
dc.date.available2023-08-23T06:09:54Z-
dc.date.issued2022-12-30-
dc.identifier.urihttps://repository.unej.ac.id/xmlui/handle/123456789/117696-
dc.description.abstractBackground: Skin graft is one of the best options for wound closure. This method is the gold standard for skin burns and large open wounds. Coffee, or Robusta coffes (BP-2) is believed to reduce the level of hyperpigmentation due to chlorogenic acid, a major polyphenolic found in coffee with anti-tyrosinase activity. However, the anti-tyrosinase activity of BP-42 coffee extract is unknown. This study aims to measure the chlorogenic acid content of BP-42 coffee bean extract and its anti tyrosinase activity. Methods: BP-42 coffee beans were extracted using ethanol by maceration technique. Then, the thin-layer chromatography (TLC) profile of the BP-42 coffee bean extract was made to determine the chlorogenic acid content. At the same time, its anti-tyrosinase activity was performed using the spectrophotometric method. The chlorogenic acid’s content was determined using the TLC-densitometric method. Data were analyzed using SPSS version 20.0 for Windows. Results: BP-42 coffee bean extract had chlorogenic acid concentrations at 12.452 mg/g extract. As expected, the extract exhibited anti-tyrosinase activity with IC50 at 312.213 ppm, while kojic acid showed higher bioactivity (IC50 = 30.696 ppm). Conclusion: BP-42 coffee bean extract showed a notable anti-tyrosinase activity, promising to be used as the natural anti pigmentation candidate.en_US
dc.language.isoenen_US
dc.publisherBali Medical Journal (Bali MedJ)en_US
dc.subjectChlorogenic aciden_US
dc.subjecthyperpigmentationen_US
dc.subjectIC50en_US
dc.subjectkojic aciden_US
dc.subjecttyrosinaseen_US
dc.titleRobusta Bp-42 Coffee Bean Extract Is a New Anti-tyrosinase Candidate to Reduce Melanogenesis Activityen_US
dc.typeArticleen_US
dc.identifier.validatorrevaen_US
Appears in Collections:LSP-Jurnal Ilmiah Dosen



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