Effectiveness of Edamame (Glycine max L. Merril) Membrane in Accelerating The Wound Healing Process of Deep-Partial Thickness Burn

Abstract

The gold standard for deep-partial thickness burns is early excision and skin grafting. However, many hospitals in Indonesia still resort to conventional treatment due to the high cost of surgery and the need for qualified medical professionals. This research aimed to investigate the effectiveness of edamame (Glycine max L. Merill) membrane as an innovative therapy for deep-partial thickness burns. Forty-eight male Wistar rats with deep-partial thickness burns were randomly assigned into four groups: control, silver sulfadiazine treatment, the membrane with 40% edamame extract, and the membrane with 60% edamame extract. Multiple serial measurements were taken at 4, 10, and 16 days to evaluate wound healing parameters, including macroscopic evaluation, histopathological examination, and hydroxyproline assessment. The results revealed that the treatment groups using edamame membrane showed significantly improved wound healing compared to the control group. Macroscopic evaluation, histopathological findings, and hydroxyproline assay confirmed the efficacy of the edamame membrane with a 60% extract concentration, which yielded the best healing outcomes. This study concluded that edamame membrane is effective as deeppartial thickness burns wound dressing.