Effect of Red (Rhodophyceae), Brown (Phaeophyceae) and Green (Chlorophyceae) Seaweed Extracts, On Platelet Counts In Diabetic Mice

Abstract

Introduction: Hyperglycemia and insulin resistance in uncontrolled diabetics induce the formation of ROS which is responsible for increased platelet activation. This has the potential for complications of arteriosclerosis and cardiovascular disease. Seaweed extract has bioactive content that functions as an antioxidant and is able to lower blood glucose levels. The bioactive content is influenced by the type of seaweed, location and also the environment. Objectives. The purpose of this study was to determine the effect of giving red, brown and green seaweed extracts on the platelet numbers of diabetic mice. Methodology: The study was conducted on 6 groups of mice, namely the normal group (without treatment) the negative control group (diabetes), the positive control group (diabetes and metformin), the diabetes group and given red seaweed extract, the diabetes group and given brown seaweed extract and the diabetes group. and given green seaweed extract. The dose of seaweed extract is 10 mg / 20 gr/BB/day and metformin is at a dose of 1.3 mg / 20 gr/BB. The platelet count was calculated directly using the Brecher Cronkite method. Results. The results showed that the platelet counts in diabetic mice were significantly higher than in the normal group and the other groups that were given metformin and seaweed. Diabetic mice given red seaweed showed no significant difference in platelet counts from the positive and normal control groups, while brown and green seaweeds showed lower platelet counts. Conclusion(s). It was concluded that the intake of seaweed extract decreased the platelet count in diabetic mice.