Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/113442
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dc.contributor.authorWICAKSONO, Yudi-
dc.contributor.authorWISUDYANINGSIH, Budipratiwi-
dc.contributor.authorSISWOYO, Tri A-
dc.date.accessioned2023-03-25T05:33:47Z-
dc.date.available2023-03-25T05:33:47Z-
dc.date.issued2017-06-17-
dc.identifier.urihttps://repository.unej.ac.id/xmlui/handle/123456789/113442-
dc.description.abstractPurpose: To investigate the formation of atorvastatin calcium (AC) co-crystal to improve its solubility and dissolution rate. Method: Co-crystallization of AC in equimolar ratio with isonicotinamide (INA) was carried out by slow solvent evaporation method using methanol. The solid obtained was characterized by powder x-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and then further evaluated for solubility and dissolution. Results: The PXRD pattern of ACINA showed new crystalline peaks at 2θ values of 8.2 and 18.3o , indicating the presence of a new crystalline phase of ACINA co-crystal. The DSC thermogram of ACINA displayed a melting point at 201.7 oC which is higher than the melting points of AC (159.4 oC) and INA (158.0 oC). The FTIR spectra of AC in ACINA shifted the absorption peak from 3363 to 3280 cm-1 and to 1216 to 1222 cm-1 . The absorption peak shift is presumably due to N-H and C-N groups of AC form the hydrogen bonding interaction with groups in INA molecule. The solubility of ACINA co-crystal in distilled water was 270.7 mg/L which is significantly higher (p < 0.05) than that of pure AC (140.9 mg/L). The dissolution rate of ACINA co-crystal was 2 - 3 times faster than that of pure AC. Conclusion: AC and INA in equimolar ratio forms a co-crystal by slow solvent evaporation. ACINA cocrystal significantly increases in solubility with a dissolution rate 2 - 3 times faster than that of pure AC. The enhancement of aqueous solubility and dissolution rate of AC with co-crystallization may be a potential way to solving the bioavailability problem of AC.en_US
dc.language.isoenen_US
dc.publisherOriginal Research Articleen_US
dc.subjectAtorvastatin calciumen_US
dc.subjectCo-crystalen_US
dc.subjectIsonicotinamideen_US
dc.subjectSolubilityen_US
dc.subjectDissolution rateen_US
dc.titleEnhancement of solubility and dissolution rate of atorvastatin calcium by co-crystallizationen_US
dc.typeArticleen_US
Appears in Collections:LSP-Jurnal Ilmiah Dosen

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