Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/111757
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dc.contributor.authorYOON, Yeo-Cho
dc.contributor.authorCHOI, Hee-Jeong
dc.contributor.authorPARK, Ji-Hyun
dc.contributor.authorDINIYAH, Nurud
dc.contributor.authorSHIN, Hyun-A
dc.contributor.authorKIM, Mi-Yeon
dc.date.accessioned2023-01-25T05:02:20Z
dc.date.available2023-01-25T05:02:20Z
dc.date.issued2019
dc.identifier.urihttps://repository.unej.ac.id/xmlui/handle/123456789/111757
dc.description.abstractLong-term ultraviolet (UV) exposure accelerates the phenomenon of skin photo-aging by activating collagenase and elastase. In this study, we aimed to investigate the effects of a combination of grapefruit and rosemary extracts (cG&Re) on UVB-irradiated damage in HaCaT cells and dorsal mouse skin. In HaCaT cells, cG&Re recovered UVB-reduced cell viability and inhibited protein expression of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinases (p-Erk), c-Jun N-terminal kinases (p-JNK), and a class of MAPKs (p-P38). Also, cG&Re suppressed UVB-induced collagen and elastin degradation by decreasing matrix metalloproteinases (MMPs) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) expression, which is a transcription factor. Similar results were observed in dorsal mouse skin. Taken together, our data indicate that cG&Re prevent UVB-induced skin photo-aging due to collagen/elastin degradation via activation of MAPKs, MMPs, and the NF-κB signaling pathway in vitro and in vivo.en_US
dc.language.isoenen_US
dc.publisherThe Plant Resources Society of Koreaen_US
dc.subjectA COMBINATION OF GRAPEFRUIT AND ROSEMARY EXTRACT(cG&Re)en_US
dc.subjectMATRIX METALLOPROTEINASESen_US
dc.subjectMITOGENACTIVATED PROTEIN KINASESen_US
dc.subjectSKIN PHOTO-AGINGen_US
dc.titleCombination of Grapefruit and Rosemary Extracts Has Skin Protective Effect Through Mmps, Mapks, and the NF-kB Signaling Pathway in Vitro and in Vivo UVB-Exposed Modelen_US
dc.typeArticleen_US
Appears in Collections:LSP-Jurnal Ilmiah Dosen



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