Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/110588
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dc.contributor.authorFEBIANTI, Zahrah-
dc.contributor.authorPERMATASARI, Nur-
dc.contributor.authorSOEHARTO, Setyawati-
dc.date.accessioned2022-11-04T07:32:06Z-
dc.date.available2022-11-04T07:32:06Z-
dc.date.issued2018-11-26-
dc.identifier.govdocKODEPRODI2010101#Pendidikan Dokter-
dc.identifier.urihttps://repository.unej.ac.id/xmlui/handle/123456789/110588-
dc.description.abstractThis study was to investigate the effect of Physalis angulata L. leaf water extract on vascular rarefaction, oxidative stress, and inflammation on the kidney of Nω-nitro-L-arginine methyl ester (L-NAME)-induced male Wistar rats. Methods: A total of 25 male Wistar rats were divided into five equal groups (normal control: 40 mg/kg/day of normal saline; L-NAME group; and treatments I, II, and III: L-NAME plus P. angulata L. leaf water extract doses 500 mg/kg/day, 1500 mg/kg/day, and 2500 mg/kg/day, respectively). Endothelial dysfunction was induced by 40 mg/kg/day L-NAME intraperitoneally. The treatment lasts for 15 days. Vascular rarefaction was indicated by the decrease in vascular density, which considered as vascular number per high-power field in hematoxylin-eosin staining preparation. Kidney oxidative stress test was performed by measuring malondialdehyde (MDA) level with thiobarbituric acid reactive substances assay. The inflammatory marker was the nuclear factor kappa-lightchain-enhancer of activated B cells (NF-κB) expression which examined using an immunohistochemical method with an antibody against p65. Results: At the dose of 500 mg/kg/day and 1500 mg/kg/day, P. angulata leaf water extract supplementation increased the vascular density, decreased the MDA level, and decreased the NF-κB expression compared to the L-NAME group. Conclusion: The administration of P. angulata L. leaf water extract in particular concentration has a vasoprotective effect by preventing kidney vascular rarefaction, oxidative stress, and inflammation on L-NAME-induced male Wistar rat.en_US
dc.language.isoenen_US
dc.publisherAsian Journal of Pharmaceutical and Clinical Researchen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectKidneyen_US
dc.subjectMalondialdehydeen_US
dc.subjectNuclear factor kappa-light-chain-enhancer of activated B cellsen_US
dc.subjectNω-nitro-L-arginine methyl esteren_US
dc.subjectPhysalis angulata leafen_US
dc.subjectVasoprotective.en_US
dc.titleVasoprotective Effect of Physalis Angulata L. Leaf Water Extract on Kidney Of Nω-Nitro-L-Arginine Methyl Ester-Induced Endothelial Dysfunction Rat Modelen_US
dc.typeArticleen_US
Appears in Collections:LSP-Jurnal Ilmiah Dosen



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