Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/106573
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dc.contributor.authorFUNAYAMA, Akinori
dc.contributor.authorCHENG, Jun
dc.contributor.authorMARUYAMA, Satoshi
dc.contributor.authorYAMAZAKI, Manabu
dc.contributor.authorKOBAYASHI, Takanori
dc.contributor.authorSYAFRIADI, Mei
dc.contributor.authorKUNDU, Sukalyan
dc.contributor.authorSHINGAKI, Susumu
dc.contributor.authorSAITO, Chikara
dc.contributor.authorSAKU, Takashi
dc.date.accessioned2022-04-25T02:59:53Z
dc.date.available2022-04-25T02:59:53Z
dc.date.issued2011-02-08
dc.identifier.govdocKodeprodi#1610101#KedokteranGigi
dc.identifier.govdoc0029056802
dc.identifier.urihttp://repository.unej.ac.id/xmlui/handle/123456789/106573
dc.description.abstractObjective: Podoplanin, a known lymphatic endothelial cell marker, has been reported to be expressed in various types of cancer. To elucidate the expression of podoplanin in precancerous lesions, we examined the immunohistochemical profiles of podoplanin in oral squamous epithelial lesions. Method: We studied a total of 298 foci of squamous cell carcinoma (SCC), carcinoma in situ (CIS), epithelial dysplasia, and hyperplastic and/or normal epithelial lesions by immunohistochemistry using D2-40. Results: There was no positivity for podoplanin in normal or hyperplastic epithelia, while all of the CIS and SCC foci stained positive. Approximately one third of the mild dysplasia foci (10 of 36 foci, 28%) and 80% of moderate dysplasia foci (78/98) showed grade 1 positive reactions (positive only in the 1st layer). Grade 2 reactions (up to 4th layer) were seen in 4 of 98 moderate dysplasia foci (4%), 29 of 74 CIS foci (39%), and 3 of 30 SCC foci (10%). Grade 3 reactions (to more than 5th layer) were found in 35 (47%) CIS foci and 26 (87%) SCC foci. Conclusions: The relationship between the present histological categorization and podoplanin grade was statistically significant. D2- 40 expression is considered to be related to the severity of oral precancerous lesions.en_US
dc.language.isoenen_US
dc.publisherPathobiologyen_US
dc.subjectCARCINOMA IN SITUen_US
dc.subjectD2-40en_US
dc.subjectEPHITELIAL DYSPLASIAen_US
dc.subjectORAL MUCOSAen_US
dc.subjectPODOPLANINen_US
dc.subjectSQUAMOUS CELL CARCINOMAen_US
dc.titleEnhanced Expression of Podoplanin in Oral Carcinomas in situ and Squamous Cell Carcinomasen_US
dc.typeArticleen_US
dc.identifier.validatortaufik 7 november 2023
Appears in Collections:LSP-Jurnal Ilmiah Dosen



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