Meloxicam Self-Nanoemulsifying Drug Delivery System: Formulation And Release Kinetics Analysis

Abstract

he oral route is the main route of drug delivery for various diseases. Fifty percent of oral administration of drugs is inhibited due to low drug solubility [1], whereas according to the Noyes Whitney equation, drug solubility is directly proportional to the dissolution rate. Drug dissolution in biological systems is a vital attribute before systemic absorption. In vitro drug dissolution study is a relatively fast and inexpensive technique to predict absorption in vivo of a drug formulation [2]. The dissolution study can reflect differences in bioavailability due to formulation factors [3]. For drugs with low solubility, appropriate formulation methods are needed to increase their solubility. Meloxicam is a class II Biopharmaceutical Classification System (BCS) [4], which has very low solubility in water (4.4 g/ml, 25 °C) [5]. This study used a lipid-based drug delivery system, a self-nano emulsifying drug delivery system (SNEDDS), to increase meloxicam solubility. SNEDDS has an advantage in increasing the surface area leading to increased lipophilic drug dissolution and absorption