Cassava Leaves Extract (Manihot esculenta) Prevents the Decrease of Albumin Serum Level in Mice with Gentamicin-Induced Hepatotoxicity

Abstract

gentamicin is effectively used for the treatment of gram-negative bacterial infection but it has a hepatotoxic effect. Lipid peroxidation and suppression of endogenous antioxidants by gentamicin increases the production of reactive oxygen species which leading to necrosis ofthepatocyte. Cassava leaves (Manihot esculenta) contain phenolic compounds, flavonoids, vittamin C, carotene, and iron which act as antioxidant and enzymatic antioxidant cofactor which can inhibit lipid peroxidation.