Cassava Leaf Flavonoid Extract on Enhancing the Gingival Epithelium Thickness of Lipopolysaccharide-Induced Rats

Abstract

This study was aimed to determine the effect of administration of flavonoid extract gel of cassava leaves (Manihot esculenta) on gingival epithelial thickness in rat models induced by periodontitis lipopolysaccharide (LPS) of E. coli. This study was an experimental laboratory research on 27 male Wistar rats randomly divided into 9 groups induced by lipopolysaccharide. Groups K11, K12, and K13 were the control groups, and groups P11, P12 and P13 groups were treatment groups with 25% flavonoid extract gel of cassava leaves; while P21, P22, and P23 groups were treatment groups with 50% flavonoid extract gel of cassava leaves. K11, P21, P31 were decapitated on day 3; K12, P12, P22 were decapitated on day 7; K13, P13, and P23 were decapitated on day 14. The measured parameter was the thickness of the epithelium after the lipopolysaccharide was induced. Data analysis used one way ANOVA. Flavonoid extract of cassava leaf (Manihot esculenta) at concentrations of 25% and 50% are not effective in increasing the thickness of the gingival epithelium of the periodontitis rat model, which are decapitated either on day 3; 7th day; or 14th day.