Neuroprotective Potency of Tamarindus indica Seed Extract for Preventing Memory Impairment in Rat Model of Alzheimer's Disease

Abstract

Objective: To investigate the neuroprotective potency of Tamarindus indica seed extract (TSE) for Alzheimer's prevention-based on the pathogenesis of the disease. Methods: Rats were divided into 6 groups: normal, control, aluminum chloride (AlCl 3 ), low, moderate and high dose of TSE. The Morris water maze test was used to evaluate the memory. Proinflammatory cytokines levels were estimated by enzyme-linked immunosorbent assay method. Malondialdehyde levels were measured by the thiobarbituric acid reactive substances method. Results: Administration of 50 mg/kg TSE were decreased cerebral cortex levels of proinflammatory cytokines and lipid oxidation products, and protected memory impairment due to the induction of AlCl 3 . Conclusion: Data from this study confirmed the neuroprotective benefits of TSE for Alzheimer’s prevention based on the pathogenesis of the disease. Further, these results could lead to the development of Alzheimer's prevention.