Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/101528
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dc.contributor.authorKURNIAWATI, Atik-
dc.contributor.authorSAPUTRA, Dwi Riski-
dc.contributor.authorSARI, Dewi Yunita-
dc.contributor.authorAMANITHA, Indhi Cinthiya-
dc.contributor.authorHARIYATI, Siti Nurul Masruroh-
dc.date.accessioned2020-11-02T05:41:39Z-
dc.date.available2020-11-02T05:41:39Z-
dc.date.issued2020-07-01-
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/101528-
dc.description.abstractIntroduction: Based on epidemiological data, the periodontitis prevalence in Indonesia reached 96.58%. Periodontitis is a periodontal disease caused by specific microorganisms causing attachment loss, alveolar bone resorption, and periodontal pocket. The pocket which is more than 6 mm couldn’t be carried out using standard care. Therefore bone grafting is needed to fix the bone defect. Cowhide Gelatin nanoparticle (GNPs) combined with TitaniumPrepared Platelet-Rich Fibrin (T-PRF) is an innovative healing of periodontitis. Objective: To review the potential of cowhide gelatin nanoparticles combined with titanium-prepared platelet-rich fibrin (T-PRF) as an innovation in the healing of periodontitis defects. Literature review: Cowhide GNPs are the main ingredients for the bone replacement, which are nano-sized, biocompatible, bioactive, osteoconductive, non-toxic, and have a porous structure that supports the drug-delivery process. T-PRF contains platelets, fibrin, growth factors that can stimulate bone regeneration. Discussion: GNPs support the attachment and proliferation of osteoblast cells and the formation of mineralized bone matrix. The contents of T-PRF, which are fibrin, platelets, and growth factors, one of TGF-β1 will produce bone formation and periodontal healing in the large number. Moreover, T-PRF has leukocyte-fibrin, which may give an antibacterial effect. Thus, GNPs combined with T-PRF have more potent properties that support each other in carrying out their functions to stimulate the healing process. Conclusion: The combination of cowhide gelatin nanoparticles (GNPs) and titanium-prepared platelet-rich fibrin (T-PRF) has the potential to be effective in bone regeneration in periodontitis defects.en_US
dc.language.isoInden_US
dc.publisherODONTO Dental Journal. Volume 7. Nomor 1. Juli 2020en_US
dc.subjectgelatin nanoparticlesen_US
dc.subjectperiodontitisen_US
dc.subjectT-PRFen_US
dc.titleCowhide Gelatin Nanoparticles and Titanium-Prepared Platelet-Rich Fibrin Potential in Periodontitis Healing Processen_US
dc.typeArticleen_US
dc.identifier.kodeprodiKODEPRODI1610101#Kedokteran Gigi-
dc.identifier.nidnNIDN0004027108-
Appears in Collections:LSP-Jurnal Ilmiah Dosen

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