Cacao Seed (Theobroma cacao L.) Extract Gel Effect on the Neutrofil Number After Tooth Extraction

Abstract

Background: Tooth extraction is tooth removal procedure from the alveolar socket. Tooth extraction causes wounds in the form of exposed alveolar bone to the oral cavity where the treatment should be observed. Wound healing is begun by an inflammatory phase. The first defense cells that come to the wound tissue are neutrophils. The excessive post-traumatic inflammation can cocoa bean extract, neutrophils, tooth extraction lead neutrophils to be overactivated. This condition may prolong and aggravate the inflammatory response. This study is to determine the effect of cocoa seed extract gel to the number of neutrophil. Method: This research was an experimental research laboratories with the post test control group design. 24 male Wistar rats were used to be the sample. The sample were divided into 2 groups which were control and treatment group. Cocoa seed extract gel was given to the treatment group, whereas the control group didnt given the cocoa seed extract gel. The treatment and control groups were performed decaputation on the 1st, 3rd, and 7th days after tooth extraction. After decaputation was performed, socket tissue was taken to make histological preparation which was stained by Hematoxylin Eosin. Result: The neutrophils average of the treatment group is lower than control group in the 1st, 3rd, and 7th day. Conclusion: The result of the study showed that the 8% cocoa (Theobroma cacao L.) bean gel extract could reduce the neutrophils in rat post-extraction tooth socket.