| dc.description.abstract | ABSTRACT
5-fluorouracil is an antineoplastic agent as an antimetabolite that used
for treating breast, colorectal and gastric cancers. Several compound as a
derivative 5 fluorouracil has been synthesis for increase its activity and reduce
side effect. 1-(3,4-dichlorobenzoyloximetil)-5 fluorouracil is a derivative of 5
fluorouracil that synthesized for development drugs. Synthesis 1-(3,4dichlorobenzoyloxymethyl)-5
fluorouracil
has
two
step.
The
first
step
is
alkylation
between 5-fluorouracil and formaldehyde to produce 1-hydroxymethyl-5fluorouracil.
The second step is benzoylation between 1-hydroxymethyl-5fluorouracil
and 3,4-dichlorobenzoylchloride to give the target compound, 1(3,4-dichlorobenzoyloxymethyl)-5-fluorouracil.
This
compound
has
been
purified
by
Column
Chromatography
and
give
white
color
with
melting
point
184-186
C
and then fix identification by H-NMR 500 MHz and KBr FTIR. 1-(3,4dichlorobenzoyloxy
methyl)-5-fluorouracil probably can synthesed and resuted
±9,27 % of yield and its unstability that caused still have degradan 3,4dichlorobenzoic
acid. | en_US |
