OPTIMASI KOMPOSISI PELARUT GLISERIN DAN PROPILENGLIKOL TERHADAP DISOLUSI TABLET MELOKSIKAM METODE LIKUISOLID MENGGUNAKAN SIMPLEX LATTICE DESIGN

Abstract

Meloxicam is NSAID (Non Steroid Inflammation Drugs) that inhibit ciclooxigenase (COX-2). Meloxicam has poor solubility in water. The drug that has poor solubility, need to be modified to increase the solubility. The technique that can increase the solubility is liquisolid technique. The research aim was to develope tablet formulation of meloxicam by increasing the solubility using liquisolid method. This liquisolid tablet used combination of propylene glycol and glycerin as nonvolatile solvent to increase meloxicam release. The liquisolid tablets were evaluated for physical chemical characteristics e.g homogenity level, drug content uniformity, friability, hardness, disintegration time and in vitro drug release. Optimization composition of propylene glycol and glycerin used simplex lattice design method with nonvolatile solvent as a factor and DE60 as response. The use propylene glycol and glycerin will increase drug release. Optimum composition of propylene glycol and glycerin resulting optimum DE60 between 78,88% until 88,48% was propylene glycol between 0 mg until 15 mg while glycerin between 0 mg until 15 mg in 300 mg of tablet.