| dc.description.abstract | The purpose of this research was to know the best formulation that can be form in
development of sustained release dosage form based EC – HPMC matrix systems by
solid dispersion technique. The result of this research expected can be used to next
test according to in vivo method. Etilcellulose N22 is a hydrophobic polymer with
high viscosity 20cps. With this high viscosity, EC can be used as a matrix in
controlled release drug delivery systems. Addition HPMC as combination is to
decrease excessive erosion, so this sustained release dosage form become stable in its
release. Diclofenac sodium (ND) is a drug material that can used in sustained release
by solid dispersion with EC (1:3) in formula F1, F2, F3. Addition of HPMC in each
formula F1, F2 and F3 (5%, 10%, 15%) help matrices to controlling the release
rates. Drug release profile of Diclofenac Sodium from matrix were evaluated in vitro
by using dissolution apparatus type I with 50 rpm stirring rotation in base media of
pH 6,8 for 8 hours. The sample solutions were analyzed for Diclofenac Sodium by UV
absorbance at 281 nm using Spectrophotometer UV-Vis U1800. The result showed
that the release of Diclofenac Sodium from EC matrix without combination with
HPMC was able to perform an ideal formulation of sustained release dosage form.
There was no significant difference in drug release between the hydrophyllic matrices
when the HPMC concentration was modified in low percentage (5%). The best-fit
release kinetics with the highest correlation coefficient was achieved with the
Higuchi method, followed by the first-order plot and the zero-order equations,
respectively, over 8 hour. | en_US |
