| dc.description.abstract | The purpose of this research was to study the activity of Sonchus arvensis leaves
extract as antihyperuricemics agent on hyperuricemic male mice. Eighteen male mice
were divided into six groups, i.e the first group as a normal control K(N); the second
group as a negative control K(-) treated chicken liver juice 0,2 % b/v orally; the third
group as a positive control K(+) treated allopurinol 10 mg/kgBW orally; the fourth to
six groups P1, P2, and P3 were treated with n-hexane, ethyl acetate, and ethanol
70% of Sonchus arvensis leaves extract 300 mg/kgBW orally for 4 days. Pottasium
oxonate 300 mg/kgBW i.p was induced 1 hour before the blood samples was
collected. The blood samples was taken from vena ophtalmicus. The concentration of
uric acid was determined with FS DHBSA. Data was analyzed using one way ANOVA
and LSD test. The result showed that activity of ethyl acetate and ethanol 70% extract
of Sonchus arvensis leaves has significant effect in reducing the concentration of uric
acid in hyperuricemic mice. Base on phytochemistry screening it has saponin,
flavonoid, steroid, and terpenoid. The substance that estimated has antihyperuricemic
activity was flavonoid | en_US |
