|dc.description.abstract||The role of C. albicans as pathogen opportunistic in oral infection can
affected by immune system. Phagocytosis has contributed in immune system against C.
albicans infection, which is the role of monocytes. Coffee has been proved to increase
monocyte’s phagocytic activity, but the effect of robusta coffee leaves extract (EDKR) to
increase monocyte’s phagocytic activity on C. albicans is unknown. Objectives:To
determine the effect of coffee robusta leaves on monocyte’s phagocytic activity on C.
albicans. Methods: This research was acted invitro on human monocyte cell culture.
There was 5 groups: negative control group, positive control group (incubated in
Isoprinosine) and treatment groups was incubated in EDKR 2,5%, 5%, 10%. The
percentage of activated monocytes was counted. Result: The result showed that
incubation of EDKR 2,5%, 5% and 10% could increase monocyte’s phagocytic activity
significantly (p<0,05) compared to control groups. The number of monocyte’s
phagocytosis on C. albicans incubated with EDKR 2,5%, 5% and 10% is 65%, 60,5%,
and 58,75%. The optimal concentration of EDKR to increase monocyte’s phagocytic
activity was 2,5%. Conclusion: The study showed that EDKR can increase monocyte’s
phagocytic activity on C. albicans.||en_US