Now showing items 1-3 of 3

    • Dental metal-induced innate reactivity in keratinocytes 

      Rachmawati, Dessy; Buskermolen, Jeroen K.; Scheper, Rik J.; Gibbs, Susan; Blomberg, B. Mary E. von; Hoogstraten, Ingrid M.W. van (2018-09-07)
      Gold, nickel, copper and mercury, i.e. four metals frequently used in dental applications, were explored for their capacity to induce innate immune activation in keratinocytes (KC). Due to their anatomical location the ...
    • Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury) 

      Rachmawati, Dessy; Alsalem, Inas W.A; Bontkes, Hetty J.; Verstege, Marleen I.; Gibbs, Sue; Blomberg, B. Mary E. von; Scheper, Rik J.; Hoogstraten, Ingrid M. W. van (2018-07-24)
      Nickel, cobalt and palladium ions can induce an innate immune response by triggering Toll-like receptor (TLR)-4 which is present on dendritic cells (DC). Here we studied mechanisms of action for DC immunotoxicity to gold ...
    • Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators 

      Rachmawati, Dessy; Bontkes, Hetty J.; Verstege, Marleen I.; Muris, Joris; Blomberg, B. Mary E. von; Scheper, Rik J.; Hoogstraten, Ingrid M. W. van (2018-07-24)
      Background. Nickel was recently identified as a potent activator of dendritic cells through ligating with human Toll-like receptor (TLR)-4. Contact Dermatitis Objectives. Here, we studied an extended panel of transition ...