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Dental metal-induced innate reactivity in keratinocytes
(2018-09-07)
Gold, nickel, copper and mercury, i.e. four metals frequently used in dental applications, were explored for their
capacity to induce innate immune activation in keratinocytes (KC). Due to their anatomical location the ...
Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators
(2018-07-24)
Background. Nickel was recently identified as a potent activator of dendritic cells
through ligating with human Toll-like receptor (TLR)-4.
Contact Dermatitis
Objectives. Here, we studied an extended panel of transition ...
Metal ions potentiate microglia responsiveness to endotoxin
(2018-07-24)
Oral metal exposure has been associated with diverse adverse reactions, including neurotoxicity. We showed
previously that dentally applied metals activate dendritic cells (MoDC) via TLR4 (Ni, Co, Pd) and TLR3 (Au). It
is ...
Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury)
(2018-07-24)
Nickel, cobalt and palladium ions can induce an innate immune response by triggering Toll-like receptor
(TLR)-4 which is present on dendritic cells (DC). Here we studied mechanisms of action for DC immunotoxicity
to gold ...
Immunostimulatory capacity of dental casting alloys on endotoxin responsiveness
(2018-07-24)
Statement of problem. Oral metal exposure has been associated with systemic and local adverse
reactions, probably due to elemental release from the alloys. Although supraphysiological concentrations
of salts from dentally ...
Continuing the quest for autoimmunity due to oral metal exposure
(2018-07-24)
Aim: The role of metal exposure in the development of autoimmune disease (AID) is still
controversial. Here, we studied the relationship between oral metal exposure, metal allergy and
autoimmunity. Methods: A mixed ...