Efek Seduhan Kopi Robusta terhadap Laju Endap Darah Pada Tikus yang Diinduksi Periodontitis (The Effect of Coffee Brewing in Erythrocyte Sedimentation Rate in Rat Induced Periodontitis)

Abstract

Background: Porphyromonas gingivalis is the most etiology of Periodonti tis. The bacteria harm the gingiva and lead systemic inflammation by the circulation in bloodstream. The systemic inflammation is frequently correlated with the increased levels of fibrinogen. Thus, erythrocytes lose their electron charge electron, subswquently this condition increases erythrocyte sedimentation rate (ESR). ESR is a one one of the blood screening parameter to investigate inflammation. Inflammation may be inhibited by natural ingredients which exhibit anti inflammatory effect. One of the natural products predicted to possess antiinflammatory effect is robusta coffee. Objective: to investigate the effect of coffee brewing in the erythrocyte sedimentation rate of rat induced periodontitis. Methods: Rat models were divided into 3 groups: control group, Periodontiti s group, and Periodontitis treated coffee brewing group with 28 days of treatment. Periodontitis models were injected by Porphyromonas gingivalis, wire ligature attachment on the left lower jaw. Coffee brewing treatments was given 0,6 ml/day for 28 days. The ESR was observed by westegren method. Result: The periodontitis group presented the highest ESR among the groups, while the lowest value was presented control group. Moreover, there were statistically significant difference (p<0,05) between groups. Conclusion: It is concluded there was an effect of coffee brewing to erythrocyte sedimentati on rate, which coffee brewing decreased ESR.