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DC Field | Value | Language |
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dc.contributor.author | PALUPI, Dian Retno | |
dc.date.accessioned | 2013-12-12T09:39:48Z | |
dc.date.available | 2013-12-12T09:39:48Z | |
dc.date.issued | 2013-12-12 | |
dc.identifier.nim | 092210101068 | |
dc.identifier.uri | http://repository.unej.ac.id/handle/123456789/8660 | |
dc.description.abstract | ABSTRACT 5-fluorouracil is an antineoplastic agent as an antimetabolite that used for treating breast, colorectal and gastric cancers. Several compound as a derivative 5 fluorouracil has been synthesis for increase its activity and reduce side effect. 1-(3,4-dichlorobenzoyloximetil)-5 fluorouracil is a derivative of 5 fluorouracil that synthesized for development drugs. Synthesis 1-(3,4- dichlorobenzoyloxymethyl)-5 fluorouracil has two step. The first step is alkylation between 5-fluorouracil and formaldehyde to produce 1-hydroxymethyl-5- fluorouracil. The second step is benzoylation between 1-hydroxymethyl-5- fluorouracil and 3,4-dichlorobenzoylchloride to give the target compound, 1- (3,4-dichlorobenzoyloxymethyl)-5-fluorouracil. This compound has been purified by Column Chromatography and give white color with melting point 184-186oC and then fix identification by H-NMR 500 MHz and KBr FTIR. 1-(3,4- dichlorobenzoyloxy methyl)-5-fluorouracil probably can synthesed and resuted ±9,27 % of yield and its unstability that caused still have degradan 3,4- dichlorobenzoic acid. | en_US |
dc.language.iso | other | en_US |
dc.relation.ispartofseries | 092210101068; | |
dc.subject | 5-fluorouracil, 1-(3,4-dichlorobenzoyloxymethyl)-5-fluorouracil, anticancer, benzoylation viii | en_US |
dc.title | Sintesis 1-(3,4-Diklorobenzoiloksimetil)-5- Fluorourasil sebagai Pengembangan Obat Kanker | en_US |
dc.type | Other | en_US |
Appears in Collections: | UT-Faculty of Pharmacy |
Files in This Item:
File | Description | Size | Format | |
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Dian Retno Palupi (092210101068)_1.pdf | 186.56 kB | Adobe PDF | View/Open |
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