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Title: | Potensi Minyak Ikan Lemuru (Sardinella longiceps) terhadap Jumlah Kondrosit Sendi Temporomandibula Tikus Osteoartritis |
Authors: | Roshida, Anindya Robin, Dwi Merry Christmarini Corvianindya, Yani |
Keywords: | fish oil osteoarthritis the number of chondrocytes |
Issue Date: | 28-Jul-2017 |
Abstract: | Background: The formation of prostaglandins and thromboxane in temporomandibular joint osteoarthritis trigger the production of pro-inflammatory cytokines that can degrade extracellular matrix and cause the number of chondrocytes decreased. Lemuru fish oil (Sardinella longiceps) are anti-inflammatory and may affect the number of chondrocytes. Purpose: To determine the potency of lemuru fish oil to the number of temporomandibular joint chondrocytes in osteoarthritis rats. Methods: 36 rats were injected intraarticularly by CFA on the right of the temporomandibular joint. Four weeks after injection, rats were given saline (K(-)), piroxicam (K(+)), and lemuru fish oil (P). Rats were sacrificed on day 7, 14, and 21. The number of chondrocytes was calculated in mature zone with HE staining. Result: There was increasing number of chondrocytes significantly in treatment group compared with negative or positive control group on day 14 and 21. Conclusion: Lemuru fish oil (Sardinella longiceps) can inhibit inflammation like piroxicam and may improve the number of temporomandibular joint chondrocytes in rats with osteoarthritis. |
Description: | Prosiding The 4th Dentistry Scientific Meeting of Jember 2017 “Improving Competency in Dentistry” |
URI: | http://repository.unej.ac.id/handle/123456789/80488 |
ISBN: | 978-602-61803-1-5 |
Appears in Collections: | LSP-Conference Proceeding |
Files in This Item:
File | Description | Size | Format | |
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2. Anindya Roshida _O_.pdf | 681.41 kB | Adobe PDF | View/Open |
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