COCRYSTAL OF ATORVASTATIN CALCIUM – MALONIC ACID

Abstract

Cocrystal is a relatively new solid form of active pharmaceutical ingredient that offers an alternative platform in improving physicochemical properties of active pharmaceutical ingredients Padrela et al., 2009; Mashhadi et al., 2004. Cocrystal is defined as a stoichiometric multi-component system connected by non-covalent interactions where all the components neutral and solid under ambient conditions Thakuria et al., 2013. Cocrystal can be constructed through interaction hydrogen bonding, pi-stacking, and van der Waals forces  Mashhadi et al., 2004. A pharmaceutical cocrystal is composed of an API and an appropriate coformer as carboxylic acids and amides Qiao et al., 2011. Cocrystallization of active pharmaceutical ingredient is an opportunity for enhancement of important physiochemical properties of an active pharmaceutical ingredient without changing its molecular structure Maeno et al., 2014.