PENGEMBANGAN MINYAK JAHE (Zingiber officinale) SEBAGAI PILIHAN TERAPI NYERI KRONIK PADA KEADAAN NEUROPATI DAN INFLAMASI

Abstract

Chronic pain is a pain with duration more than six months that can be induced by chronic inflammation and neuropathy. This study was aimed to analyze the component of red ginger oil and proved its antihyperalgesia activity in chronic pain that was caused by chronic inflammation and neuropathy. Forty eight mice were divided into 2 groups ie inflammatory and neuropathy. Each groups were divided into 6 subgroups (sham, CFA or PSNL, red ginger oil doses 100, 200, 400 and 600 mg/kg). Inflammatory group was induced using CFA 40 µl intraplantar. Neuropathy group was induced by PSNL method. At day-7, all groups were given treatment once daily for seven days. Hyperalgesia and plantar thickness were measured at day 0,1,3,5,7,8,10,12 and 14. Quality of Red ginger oil was standarized by SNI 06-1312-1998. The red ginger oil compound was identified by GC/MS. The result showed that red ginger oil was qualified based on SNI 06-1312-1998. Camphene was the highest compound by GC/MS analysis. Red ginger oil administration in mice prolonged latency time toward thermal stimulus and significantly different with CFA and PSNL group. The conclusion of this study that red ginger oil have antihyperalgesia activity in mice with chronic pain.