Molecular Modeling and Synthesis of 1-(3,4-dichlorobenzoyl)-1,3-dimethylurea

Abstract

Several studies have been developed on urea derivatives as Chk1 inhibitors. As a part of our research for novel anticancer agent, we designed synthesized 1-(3,4-dichlorobenzoyl)-1,3-dimethylurea. Docking simulation was performed using Molegro Virtual Docker of the Chk1 in complex with an inhibitor to explore the binding modes of this compound at the active site.