PENGEMBANGAN MINYAK JAHE (Zingiber officinale) SEBAGAI PILIHAN TERAPI NYERI KRONIK PADA KEADAAN NEUROPATI DAN INFLAMASI

Abstract

This study aims to prove antihyperalgesia activity of red ginger oil in chronic pain because of chronic inflammation. Twenty five mice were divided into 5 groups (sham, CFA, red ginger oil doses 100,200 and 400 mg/kbBW). Each group was induced chronic inflammation by CFA 40 μl intraplantar and sham groups was induced by normal saline. At days-7, all groups were given by treatment once daily for seven days. At days-14, all mice were sacrificed. Hyperalgesia and plantar thickness were measured at day 0,1,3,5,7,8,10,12 and 14. Red ginger oil was qualified by SNI 06-1312-1998 as standar and Camphene was the highest compound by GC/MS analysis. Red ginger oil administration in mice prolonged latency time with thermal stimulus and the activity was dose dependent and decreased the plantar thickness but was not significantly different with CFA groups. The conclusion of this research is red ginger oil have antihyperalgesia activity in mice with CFA-induced chronic pain