Mekanisme selular dan molekular stres terhadap terjadinya rekuren aptosa stomatitis

Abstract

Background: Recurrent aphthous stomatitis (RAS) disease has unknown etiology until now but there are many predisposing factors, including stress. Stress is a tension or pressure that affects the psyche. Stress can activate the SSP, then the stress response results in the hypothalamus secreting CRH, and CRH stimulates the pituitary to release ACTH. ACTH stimulates the adrenal cortex to produce cortisol. Glucocorticoids, including cortisol, will suppress the immune function and provide inflammatory response. Protection against microorganisms decreases, and tissue resistance also decreases. Stress also causes response which will be transmitted to the autonomic nervous system, and then to the adrenal medulla, catecholamine secretesin the form of epinephrine and norepinephrine.Catecholamine induces the release of prostaglandins and proteases that can cause tissue destruction, and inflammatory responds increases resulting in RAS.Recurrent aphthous stomatitis (RAS) is an oral mucosal ulceration, recurrent, can be characterized by single or multiple clinical symptoms, ulcers, round, diameter varies, white-colored middle part with red edge, and painful.Aim: The aim of the study was to determine the mechanism on the relationship of stress to the occurrence of RAS by cellular and molecular basis.Conclusion: The conclusion of RAS occurrence is not only due to microorganisms but also due to the psycho-neuro-immunologic system, including stress, thus the treatment should consider psychosocial treatment.