Lipopolysaccharide (LPS) Induction During Growth and Development Period of Rat Tooth Toward the Occurred of Enamel Hypoplasia

Abstract

The aim of this research is to know the effect of lipopolysaccharide (LPS) induction during growth and development period specifically the occurred of hypoplasia on tooth enamel. Male 5-day-old Wistar rats divided into two groups. Group I (control) underwent no treatment. Group II (treatment) underwent LPS induction every 24 hours for 8 days on buccal fold right maxillary first molar. After 21 days old, the rats were sacrificed and the tooth was resected. Hypoplasia Hypocalcification Index (HHI) was used to determine the degree of hypoplasia by clinical examination. Radiograph of maxilla also was taken to analyze the opacities of enamel by using Corel DRAW version 11. The result showed that group underwent LPS induction; hypoplasia was occurred on its molar tooth and more radiolucent than control group. The conclusion was that LPS induction during growth and development period of rat tooth cause enamel hypoplasia.