THE ROLE OF MATRIX METALLOPROTEINASE-8 IN ORAL DISEASES

Abstract

Background: Matrix metalloproteinase-8 (MMP-8), also known as collagenase-2 or neutrophil collagenase, was long thought to be expressed solely by maturing neutrophils, and functionally restricted to extracellular matrix (ECM) breakdown. Recent experiments, this protease can be expressed by a wide variety of cell types such as fibroblast and odontoblast, and it plays an important role in inflammation. Objectives: This review intends to give an overview the role of MMP-8 in oral diseases to be better understood and the future of our research that may facilitate the development of diagnosis and therapies. Literature review: Matrix metalloproteinases (MMPs) are a group of enzymes that responsible for the degradation of most extracellular matrix proteins. The expression and activity of MMPs is normally quite low, but increases significantly in various pathological conditions that may lead to tissue destruction. Collagenases, especially MMP-8 in dental caries and periodontitis related to increased presence and activity of MMP at the site of disease. Some dental materials can caused increased expression of this MMP. MMP inhibition has been suggested to decrease bone resorption in pathological conditions and dentinal caries progression. Conclusion: The presence of MMP-8 in inflamed pulp tissue and gingival crevicular fluid indicating that MMP-8 has a role in pulpal and periodontal inflammation, participating in tissue extracellular matrix degradation. MMP inhibitors have decreased inflammatory tissue damage, suggesting possible therapeutic benefits.