Deoxypyridinoline Sebagai Salivary Biomarker Resorpsi Tulang Penyakit Periodontal Disertai Osteoporosis

Abstract

Women will be through menstruation and menopause. Menopause causes physiology changes that related estrogens deficiency, such as osteoporosis. Osteoporosis is related increasing of periodontal disease prevalence. Periodontal disease have similarity with osteoporosis, they will show disorders in late stage. Saliva is consisted liquid from food and crevicular fluids. Deoxypyridinoline is one of pyridinium cross link in collagen, especially bone. Deoxypyridinoline is very specific because it will not re-metabolized in body and be influenced by food. Development of diagnostic tools is needed for determining diagnostic and treatment early and specific. The aim of this study was to indentify and compare deoxypyridinoline level in serum and saliva of periodontal disease subject with osteoporosis. This research was case control study. This study had agreement from ethic commission Dentistry Faculty of Gadjah Mada University, Yogyakarta. Subjects were divided based on sample criteria, clinical assessment and rongent. There were 4 groups, subject without osteoporosis and periodontitis, without osteoporosis and with periodontitis osteoporosis, with osteoporosis and without periodontitis, and with osteoporosis and periodontitis. Saliva and serum saliva was analyzed by LC MS/MS method. The result showed that serum deoxypyridinoline was higher than in saliva. Deoxypyridinoline in subject with periodontitis and osteoporosis had the highest level. The conclusion showed there was significant different of deoxypyridinoline in saliva and serum. Deoxypyridinoline can be used as bone resorption parameters.