Aktivitas Antimalaria Ekstrak Metanol Dan Fraksi Kloroform Buah Duranta Repens L. Pada Mencit Yang Diinfeksi Plasmodium Berghei

Abstract

Malaria is one of tlu most prevalent infectious diseases in the tropical countries. The resistance of Plasmodium scientist to look for new drugs for many syntlutic antimalarial drugs has encowaged the from the rwture. Duranta repew L. fruit traditionally lo treat malaria This research study was conducted to examine the antimalarial activity of metlanolic extract and chloroformic fraction of D. repens L hos been used fruit infected with Plasmodium berghei. The antimalarial activily ctssa)/ wcrs catied out using Peter's Test. Twenty one Mice, weighing 20 - j0 to male mice g, were divided into 7 groups as treatments, three mice each group. Thefirst group as negative control, the second - seventh groups were treatedwilh tlu concentration of 12.5, 25, 50, 75, 100 and 150 mg/kg BW The results showed that the IC5s of methanolic extract of D- repens Lfruit was 47, 2 mg/kg BW, while the IC50 of was 38, 9 mg/kg BW. So it can be concluded that lhe D. repens L. chloroformic fraction fruit of D. repens L fruit is potentially developed as antimalarial drug.