OPTIMASI KOMPOSISI KARBOPOL DAN NATRIUM KARBOKSIMETILSELULOSA SEBAGAI SISTEM BUCCAL MUCOADHESIVE TABLET PROPANOLOL HIDROKLORIDA

Abstract

Mucoadhesive buccal tablet for the treatment of hypertension propanolol hydrochloride prepared by mixing two polymers and other excipients. The purpose of this study to provide controlled release dosage by avoiding first pass metabolism and enzymatic degradation. Propanolol hydrochloride mucoadhesive buccal tablets prepared by direct compression method using carbopol and CMC Na as buccal mucoadhesive polymer. Buccal mucoadhesive strength measured using buccal mucosa of sheep. Testing the release of propanolol hydrochloride was determined by dissolution test using phosphate buffer solution pH 6,8 for 8 hours. Dissolution efficiency (DE) calculated to describe the over all release profiles and used in determining the optimum response. The optimum region is determined using factorial design with the design criteria of response force for 20-40 grams of mucoadhesive buccal and DE480 between 45-55%. The amount of carbopol that can provide the optimum response is between the range of 53,27-55 mg while the amount of CMC Na can provide the optimum response range is between 70-100 mg.