Prospek Probiotik Dalam Pencegahan Agresifitas Resorbsi Osteoklastik Tulang Alveolar Yang Diinduksi Lipopolisakarida (Lps) Pada Penyakit Periodontal

Abstract

The purpose of this study was to determine the role of probiotics in inhibiting the activity of pathogenic bacteria oral cavity. Long-term goal is to deliver the probiotic bacteria that inhibit the bone resorption induced by pathogenic bacteria in the oral cavity. The output of this research is the appropriate concentration of probiotic bacteria and probiotic potential of the right order. This method is expected to be used for prevention and treatment of periodontal disease which is still complex and derived products with high quality probiotics. The main product is the development potential of probiotics in maintaining oral health, especially periodontal disease more effectively and efficiently. This study using rats and divided into 4 groups: Group I, control without treatment; group II, induction of LPS E. coli for 5 days, Group III, LPS induction of E. coli + Probiotic Bacteria Lactobacillus casei injection for 5 days together, and group IV, induction of LPS E. coli for 5 days + 5 days injection of Lactobacillus casei selnjutnya. After didekaputasi, research sample in the form of dental and periodontal tissues have decalsification, immunohistochemical examination to see the activity of osteoclasts in alveolar bone resorption to detect TRAP (tartarate-resistant acid phosphatase) and Carboxyterminal Telopeptide of Type 1 Collagen (1CTP) and subsequently analyzed the data collected statistically.

Kata kunci : Lipopolysaccharide (LPS), Lactobacillus casei , osteoclast, alveolar bone resorption.