Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/2700
Title: Sistensis 1-(4-Metoksibenzoiloksimetil)-5-Fluorourasil Sebagai Upaya Pengembagan Obat Antikanker
Authors: Ifada
Keywords: 5-fluorouracil derivates, anticancer, 1-(4-methoxybenzoyloxymethyl)-5- fluorouracil, benzoylation
Issue Date: 3-Dec-2013
Series/Report no.: 082210101047;
Abstract: A new compound from 5-fluorouracil (5-FU) derivatives, 1-(4- methoxybenzoyloxymethyl)-5-fluorouracil has been synthesized in a two steps reaction, alkylation (5-FU and formaldehyde to form 1-hydroxymethyl-5- fluorouracil) and esterification (1-hydroxymethyl-5-fluorouracil and 4- methoxybenzoylchloride to form 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil). Reaction product purified by chromatography column, the product has been characteryzed for physical apperance is a yellowish white, crystal and melting range 168-169OC. Based on the FTIR and 1H-NMR spectra, it showed that the purified product does not contain a single compound. This fact is supported by Thin Layer Chromatography (TLC) result showing two spots for the pressure of 1-(4- methoxybenzoyloxymethyl)-5-fluorouracil and 4-methoxybenzoate acid.
URI: http://repository.unej.ac.id/handle/123456789/2700
Appears in Collections:UT-Faculty of Pharmacy

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