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Title: P e n g a r u h P e m b e r i a n E t a n o l 1 0 % D a l a m D e x t r o s e 5 % p a d a W a k t u B e r t i n g k a t t e r h a d a p T i n g k a t K e r u s a k a n R e t i n a M e n c i t y a n g D i b e r i M e t a n o l 5 0 % P e r o r a l
Authors: N g a k a n G d e A d i t y a P e r m a d i
Keywords: K e r u s a k a n R e t i n a
Issue Date: 23-Jan-2014
Series/Report no.: 0 9 2 0 1 0 1 0 1 0 1 2 ;;
Abstract: R I N G K A S A N P e n g a r u h P e m b e r i a n E t a n o l 1 0 % D a l a m D e x t r o s e 5 % p a d a W a k t u B e r t i n g k a t t e r h a d a p T i n g k a t K e r u s a k a n R e t i n a M e n c i t y a n g D i b e r i M e t a n o l 5 0 % P e r o r a l ; N g a k a n G d e A d i t y a P e r m a d i , 0 9 2 0 1 0 1 0 1 0 1 2 ; 2 0 1 3 : 6 8 h a l a m a n ; F a k u l t a s K e d o k t e r a n U n i v e r s i t a s J e m b e r . K e r a c u n a n m e t a n o l m e r u p a k a n s a l a h s a t u d a m p a k d a r i p e n y a l a h g u n a a n a l k o h o l . D a t a k a s u s k e r a c u n a n m e t a n o l m e n u n j u k k a n p e n i n g k a t a n s e t i a p t a h u n n y a . M e n i n g k a t n y a k a s u s k e r a c u n a n m e t a n o l d a p a t d i s e b a b k a n k u r a n g p a h a m n y a m a s y a r a k a t t e n t a n g b a h a y a m e n g k o n s u m s i m e t a n o l . P e n a n g a n a n k a s u s k e r a c u n a n m e t a n o l y a n g k u r a n g c e p a t m e n i m b u l k a n k e b u t a a n p e r m a n e n b a h k a n d a p a t m e n y e b a k a n k o r b a n j i w a . M e t a n o l j i k a d i k o n s u m s i m e n y e b a b k a n a s i d o s i s m e t a b o l i k d a n k e b u t a a n y a n g t e r j a d i a k i b a t a k u m u l a s i a s a m f o r m a t p a d a o r g a n m a t a t e r u t a m a d i l a p i s a n r e t i n a . A s a m f o r m a t t e r b e n t u k d a r i m e t a b o l i s m e f o r m a l d e h i d y a n g b e r i k a t a n d e n g a n a l d e h i d d e h i d r o g e n a s e , d i m a n a f o r m a l d e h i d t e r b e n t u k d a r i p r o s e s o k s i d a s i m e t a n o l d e n g a n e n z i m a l k o h o l d e h i d r o g e n a s e . E t a n o l m e r u p a k a n a n t i d o t u m u t a m a p e n a n g g u l a n g a n k e r a c u n a n m e t a n o l . E t a n o l d a p a t d i b e r i k a n s e c a r a p e r o r a l a t a u s e c a r a i n t r a v e n a d e n g a n k a d a r e t a n o l 1 0 % d a l a m l a r u t a n d e x t r o s e 5 % . P e n e l i t i a n i n i b e r t u j u a n u n t u k m e n g e t a h u i p e n g a r u h p e m b e r i a n e t a n o l t e r h a d a p t i n g k a t k e r u s a k a n r e t i n a p a d a m e n c i t y a n g d i b e r i m e t a n o l 5 0 % p e r o r a l . J e n i s p e n e l i t i a n i n i a d a l a h t r u e e x p e r i m e n t a l l a b o r a t o r i e s d e n g a n d e s a i n P o s t T e s t O n l y C o n t r o l G r o u p D e s i g n . S e t e l a h d a t a t e r k u m p u l d i l a k u k a n e d i t i n g , c o d i n g , d a n e n t r y u n t u k k e m u d i a n d i l a k u k a n a n a l i s i s d a t a s e c a r a a n a l i t i k . P e n g o l a h a n d a n a n a l i s i s d a t a d i l a k u k a n d e n g a n p r o g r a m k o m p u t e r S t a t i s t i c P r o g r a m S o c i a l S e r v i s ( S P S S ) 2 0 . U j i y a n g d i g u n a k a n y a i t u u j i o n e w a y A n o v a u n t u k m e n g a n a l i s i s p e r b e d a a n k e r u s a k a n s e l r e t i n a a n t a r k e l o m p o k . S e t e l a h i t u d i l a n j u t k a n d e n g a n u j i P o s t H o c u n t u k m e n i l a i p e r b e d a a n t i a p m a s i n g m a s i n g k e l o m p o k . P e m i l i h a n s u b j e k p e n e l i t i a n u n t u k p e n g e l o m p o k a n d a n p e m b e r i a n p e r l a k u a n m e n g g u n a k a n s i m p l e r a n d o m s a m p l i n g d e n g a n 2 k e l o m p o k k o n t r o l v i i i http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ y a i t u k o n t r o l ( p e m b e r i a n p e l e t + a q u a d e s t ) d a n k o n t r o l n e g a t i f ( 7 g r / k g B B m e t a n o l 5 0 % ) s e r t a 3 k e l o m p o k p e r l a k u a n , y a i t u p e r l a k u a n 1 ( 7 g r / k g B B m e t a n o l 5 0 % p e r o r a l , a q u a d e s d a n p e l e t k e m u d i a n s e t e l a h 6 j a m d i b e r i k a n 1 m l / k g B B e t a n o l 1 0 % d a l a m d e x t r o s e 5 % t i a p 3 j a m ) , p e r l a k u a n 2 ( 7 g r / k g B B m e t a n o l 5 0 % p e r o r a l , a q u a d e s d a n p e l e t k e m u d i a n s e t e l a h 1 2 j a m d i b e r i k a n 1 m l / k g B B e t a n o l 1 0 % d a l a m d e x t r o s e 5 % t i a p 3 j a m ) , d a n p e r l a k u a n 3 ( 7 g r / k g B B m e t a n o l 5 0 % p e r o r a l , a q u a d e s d a n p e l l e t k e m u d i a n s e t e l a h 1 8 j a m d i b e r i k a n 1 m l / k g B B e t a n o l 1 0 % d a l a m d e x t r o s e 5 % t i a p 3 j a m ) . B e r d a s a r k a n p e n e l i t i a n i n i e t a n o l 1 0 % d a l a m d e x t r o s e 5 % t e r b u k t i d a l a m g a m b a r a n h i s t o p a t o l o g i b e r p e n g a r u h m e n g h a m b a t k e r u s a k a n r e t i n a m e n c i t y a n g d i b e r i m e t a n o l 5 0 % , y a i t u d e n g a n m e n g h e n t i k a n l a j u m e t a b o l i s m e m e t a n o l d e n g a n c a r a m e n g i k a t e n z i m a l k o h o l d e h i d r o g e n a s e . D a t a y a n g d i p e r o l e h S e s u a i h a s i l u j i o n e w a y A n o v a , d i p e r o l e h n i l a i s i g n i f i c a n c y 0 , 0 0 0 ( S i g . < 0 , 0 5 ) y a n g b e r a r t i t e r d a p a t p e r b e d a a n p e n i l a i a n h i s t o p a t o l o g i k e r u s a k a n r e t i n a p a d a 5 k e l o m p o k , y a i t u 2 k e l o m p o k k o n t r o l d a n 3 k e l o m p o k p e r l a k u a n ( t o l a k H http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ ) .
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