Effect of Bitter Melon Etanol Extract (Momordica charantia) in Inhibition of NF-KB Activation and Improvement of HDL Cholesterol Blood Level on Rattus novergicus with Atherogenic Diet

Abstract

Atherosclerosis is the most common cause of death in the world. Endothelial dysfunction, cause by the inflammation process, is an initial lesion of the development of this disease. NF-KB (Nuclear Factor Kappa Beta) is a transcription factor that plays an important role in the inflammation process. Atherogenic diet activates NF-KB and leading to inflammation. HDL cholesterol protects the vascular inflammation by uptake the lipid excess from the vessel wall.