Potensi Pemberian Ekstrak Daun Ungu terhadap Re-epitelisasi pada Luka Pencabutan Gigi Tikus Wistar

Abstract

Background: Tooth extraction is the act of removing a tooth from its socket. Tooth extraction traumatizes soft tissue and hard tissue. The action certainly causes the body to respond with a physiological healing process. However, many cases in Indonesia show the occurrence of complications after tooth extraction. The treatment that has been used so far is NSAID, such as ibuprofen, natrium naproxen, and diclofenac as an anti-inflammatory, however it has adverse long-term effects, such as stomach ulcer. In this study, active compounds from plants were used for the healing process. The purpose of this study was to determine the potential of purple leaf extract administration on wound healing, especially re-epithelialization in tooth extraction sockets studied on Wistar rat teeth. Method: This research method uses in vivo experiments, namely Wistar rats by removing the mandibular left first molar tooth. The 24 rats used were divided into 6 groups. After the teeth were extracted, then the rats were treated according to the group. The negative control group was given distilled water orally, and rats with the treatment group were given purple leaf extract orally. The treatment was given for the specified time, namely 3 days, 5 days, and 7 days. Rats were euthanized and decapitated to obtain the lower left jaw, then the tissue was processed and stained using HE staining. The preparations were observed and measured to obtain the percentage of re-epithelialization. Data were processed and tested with SPSS. Result: The results of this study showed that the average percentage of re-epithelialization of the 3rd, 5th, and 7th day treatment group was higher than the control group with significant differences only on the 5th and 7th day of the treatment group. Conclusion: From the results of this study, it can be concluded that the administration of purple leaf extract has the potential to accelerate re-epithelialization of wounds after tooth extraction of Wistar rats in the 5th and 7th day treatment groups as evidenced statistically there was an increase and there were significant differences in the 5th day treatment group and the 7th day treatment group. While in the 3rd day treatment group there was no significant difference with the control group, but there was still an increase.