Irrigation Effect of Mangosteen Pericarp Extract in Wistar Rat Root Canal on Macrophage Activities Periapical Tissue

Abstract

Root canal irrigation is an important step in supporting the succes of root canal treatment.The commonly used root canal irrigation solution is NaOCI.The disadvantage is that it is irritative and can cause pain if enters the periapical tissue. Alternative irrigation material is needed which does not cause harm,namely mangosteen pericarp extract.Mangosteen pericarp extract contains xanthones and flavonoids which can prevent the occurrence of tissue inflammation,characterized by the small number of inflammatory macrophage cells.Macrophage cells are the dominant chronic inflammatory cells.