The Effect of Extract Thymoquinone Black Cumin Seed (Nigella Sativa) Of Against Neutrophils Number in Rats Socket Post Extraction With Traumatic Tissue

Abstract

Tooth extraction may accompany by complications, such as tissue laseration, bone resorption, adjacent tooth mobility and dry socket. They caused inflammation or infection. Treatment of traumatic tissue usually given an antiinflammatory drugs,but aspirin has many side effects. To alternate from side effects then used herbal remedies, one of which has a Black Cumin active ingredient is Thymoquinone. To look at the effect of the extract thymoquinone against neutrofphils number in rats socket post extraction with traumatic tissue. Methods: In this study used 12 rats that had been done tooth extraction and expansion of the wound. Furthermore, preparations were made in areas such revocation and stained using hematoxylin-eosin. There is a significant difference between the negative control group with the positive control group and the group extract thymoquinone, but there was no significant differences between the positive control group and the group thymoquinone extract. Data were analyzed using statististical test one-way anova. Extract Thymoquinone could reduce widely inflammation respons in rats socket post extraction with traumatic tissue and its that effect similar to aspirin.