Preventive Effect of Catechin Isolate From GMB4 Clone Green Tea Green Tea in Selenite Induced Cataract

Abstract

To evaluate the efects of Catechin Isolate From GMB4 Clone Green Tea on sodium-selenite induced cataract formation. Methods: Cataract Isolate From GMB4 Clone Green Tea was induced by intraperitoneal injection of 19 µmol/kg sodium selenite to ten dayold Wistar rats. The neonatal rats were randomly divided into five groups (n=5 in each group): a control group, and four cataract- induction groups, treated with either 0, 50, 100, 200 mg/kg catechin Isolate From GMB4 Clone Green Tea. We performed slit-lamp bio microscopic analysis, level of GSH and GR. Results: Both eyes of all rats in Group 1 did not exhibit cataract formation. In Group 2, all rats developed Grade 3 cataract in the lenses of both eyes. The diference in exhibited cataract in the lens of the right eyes inall rats between Group 2 and any eyes of groups 3 or 4 were significant (P = 0.001). The mean activities of GSH and GR in Group 2 rat lenses were significantly lower than the values in lenses of all rats in Group 1 (P = 0.001, 0.003, 0.001), and in the lenses of the right eyes of rats in Groups 3 and 4 (P = 0.001, 0.020, 0.001). Conclusion: Isolate catechin can efectively prevent selenite-induced cataract formation. This efect was associated with increased level of opacity, GSH and GR activities in the lens.