Browsing LSP-Jurnal Ilmiah Dosen by Author "Bontkes, Hetty J."
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Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury)
Rachmawati, Dessy; Alsalem, Inas W.A; Bontkes, Hetty J.; Verstege, Marleen I.; Gibbs, Sue; Blomberg, B. Mary E. von; Scheper, Rik J.; Hoogstraten, Ingrid M. W. van (2018-07-24)Nickel, cobalt and palladium ions can induce an innate immune response by triggering Toll-like receptor (TLR)-4 which is present on dendritic cells (DC). Here we studied mechanisms of action for DC immunotoxicity to gold ... -
Metal ions potentiate microglia responsiveness to endotoxin
Rachmawati, Dessy; Peferoen, Laura A.N.; Vogel, Daphne Y.S.; Alsalem, Inas W.A; Amor, Sandra; Bontkes, Hetty J.; Blomberg, B. Mary E. von; Scheper, Rik J.; Hoogstraten, Ingrid M. W. van (2018-07-24)Oral metal exposure has been associated with diverse adverse reactions, including neurotoxicity. We showed previously that dentally applied metals activate dendritic cells (MoDC) via TLR4 (Ni, Co, Pd) and TLR3 (Au). It is ... -
Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators
Rachmawati, Dessy; Bontkes, Hetty J.; Verstege, Marleen I.; Muris, Joris; Blomberg, B. Mary E. von; Scheper, Rik J.; Hoogstraten, Ingrid M. W. van (2018-07-24)Background. Nickel was recently identified as a potent activator of dendritic cells through ligating with human Toll-like receptor (TLR)-4. Contact Dermatitis Objectives. Here, we studied an extended panel of transition ...