Now showing items 1-6 of 6

    • Continuing the quest for autoimmunity due to oral metal exposure 

      Rachmawati, Dessy; Muris, Joris; Scheper, Rik J.; Rustemeyer, Thomas; Kleverlaan, Cornelis J.; Feilzer, Albert J.; Blomberg, B. Mary E. von; Hoogstraten, Ingrid M. W. van (2018-07-24)
      Aim: The role of metal exposure in the development of autoimmune disease (AID) is still controversial. Here, we studied the relationship between oral metal exposure, metal allergy and autoimmunity. Methods: A mixed ...
    • Dental metal-induced innate reactivity in keratinocytes 

      Rachmawati, Dessy; Buskermolen, Jeroen K.; Scheper, Rik J.; Gibbs, Susan; Blomberg, B. Mary E. von; Hoogstraten, Ingrid M.W. van (2018-09-07)
      Gold, nickel, copper and mercury, i.e. four metals frequently used in dental applications, were explored for their capacity to induce innate immune activation in keratinocytes (KC). Due to their anatomical location the ...
    • Immunostimulatory capacity of dental casting alloys on endotoxin responsiveness 

      Rachmawati, Dessy; Blomberg, B. Mary E. von; Kleverlaan, Cornelis J.; Scheper, Rik J.; Hoogstraten, Ingrid M. W. van (2018-07-24)
      Statement of problem. Oral metal exposure has been associated with systemic and local adverse reactions, probably due to elemental release from the alloys. Although supraphysiological concentrations of salts from dentally ...
    • Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury) 

      Rachmawati, Dessy; Alsalem, Inas W.A; Bontkes, Hetty J.; Verstege, Marleen I.; Gibbs, Sue; Blomberg, B. Mary E. von; Scheper, Rik J.; Hoogstraten, Ingrid M. W. van (2018-07-24)
      Nickel, cobalt and palladium ions can induce an innate immune response by triggering Toll-like receptor (TLR)-4 which is present on dendritic cells (DC). Here we studied mechanisms of action for DC immunotoxicity to gold ...
    • Metal ions potentiate microglia responsiveness to endotoxin 

      Rachmawati, Dessy; Peferoen, Laura A.N.; Vogel, Daphne Y.S.; Alsalem, Inas W.A; Amor, Sandra; Bontkes, Hetty J.; Blomberg, B. Mary E. von; Scheper, Rik J.; Hoogstraten, Ingrid M. W. van (2018-07-24)
      Oral metal exposure has been associated with diverse adverse reactions, including neurotoxicity. We showed previously that dentally applied metals activate dendritic cells (MoDC) via TLR4 (Ni, Co, Pd) and TLR3 (Au). It is ...
    • Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators 

      Rachmawati, Dessy; Bontkes, Hetty J.; Verstege, Marleen I.; Muris, Joris; Blomberg, B. Mary E. von; Scheper, Rik J.; Hoogstraten, Ingrid M. W. van (2018-07-24)
      Background. Nickel was recently identified as a potent activator of dendritic cells through ligating with human Toll-like receptor (TLR)-4. Contact Dermatitis Objectives. Here, we studied an extended panel of transition ...